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業績詳細

業績項目 学術雑誌論文(学内)
タイトル・書名 Expression of RAE-1, a ligand of the NKG2D Receptor, in Mice Adipocytes
著者
学部・講座・部門
施設
IIZUMI Kyoichi
2011  年度
医学部 衛生学 部門なし
2011  年度
旗の台校舎
著者
学部・講座・部門
施設
TATEMICHI Masayuki
2011  年度
医学部 衛生学 部門なし
2011  年度
旗の台校舎
著者
学部・講座・部門
施設
NAKADATE Toshio
2011  年度
医学部 衛生学 部門なし
2011  年度
旗の台校舎
雑誌名 Showa Univ J Med Sci
巻・号 23 巻      3 号
開始・終了ページ 開始 181  ページ /  終了  189  ページ
刊行年月 2011 年 09 月
言語 英語
内容記述 Although epidemiological evidence has confirmed the role of heavy alcohol consumption as an established risk factor for esophageal, liver, and breast cancers, the molecular mechanisms underlying this effect are not fully understood, particularly with regard to breast cancer. In this study, expression of the retinoic acid early inducible-1 (RAE-1) gene was determined in mice adipocytes. RAE-1 is a ligand of the natural-killer group 2 member D (NKG2D) receptor, which plays a crucial role in tumor immunity. RT-PCR and Western blotting analysis demonstrated that TNF-α treatment induced RAE-1 mRNA and RAE-1 protein expression in adipocytes obtained from differentiated 3T3-F442A cells. Real-time RT-PCR analysis showed that 300 mM ethanol enhanced RAE-1 mRNA expression, which peaked 6 h after administration. In addition, RAE-1 mRNA was detected in visceral adipose tissue obtained from mice. These observations indicate that RAE-1mRNA is expressed in adipocytes and that its expression is enhanced by TNF-α, which has been shown to be induced in adipose tissue by long-term alcohol consumption. Furthermore, ethanol directly enhanced RAE-1 mRNA expression, suggesting that alcohol consumption enhances RAE-1 expression in adipose tissue and might modify tumor immunity. This finding might provide novel insight into the mechanism of alcohol-associated carcinogenesis.
出版者 Showa Medical Association and Showa University
ISSN 0915-6380
医中誌ID 2012230544
資源識別子URI http://researchers-achievements.showa-u.ac.jp/dispGyoseki/?item_id=2923&item_no=1
査読 あり
論文種別 原著