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業績詳細

業績項目 学術雑誌論文(学内)
タイトル・書名 Non-touch, Quick Removal of an Occluding Intratracheal Balloon Using High Intensity Focused Ultrasound and Limonene Emulsion
著者
学部・講座・部門
施設
ANDO Shinsuke
2018  年度
医学部 外科学 小児外科学
2018  年度
昭和大学病院・東病院
著者
学部・講座・部門
施設
MARUYAMA Kazuo


著者
学部・講座・部門
施設
SUZUKI Ryo


著者
学部・講座・部門
施設
SOBHAN Ubaidus


著者
学部・講座・部門
施設
Mochizuki Takashi


著者
学部・講座・部門
施設
YAMASHITA Hiromasa


著者
学部・講座・部門
施設
CHIBA Toshio


著者
学部・講座・部門
施設
TOKI Akira
2018  年度
医学部 外科学 小児外科学
2018  年度
昭和大学病院・東病院
雑誌名 Showa Univ J Med Sci
巻・号 30 巻      3 号
開始・終了ページ 開始 351  ページ /  終了  357  ページ
刊行年月 2018 年 09 月
言語 英語
内容記述 In recent years, fetal endoscopic tracheal occlusion (FETO) using a balloon has been clinically employed for promoting prenatal lung growth to ameliorate postnatal respiratory failure caused by severe in utero lung hypoplasia. After a successful FETO, in some limited fetal centers, planned or emergency balloon removal using another fetoscopy is performed to release the tracheal occlusion immediately before delivery. To overcome this additional fetoscopy, we previously reported an innovative simple procedure to remove the occluding balloon by bursting it with a pre-planned sequence of high intensity focused ultrasound (HIFU) irradiation. In that previous study, which used rabbits euthanized and submerged in degassed water, we inflated the balloon by injecting a mixture of perfluorocarbon and ultrasound contrast medium through a fetoscopically-guided catheter. The rate of successful balloon burst and deflation using HIFU irradiation was high enough (100%), but the mode and timing of tracheal reopening (i.e., sudden burst or slow shrinkage of the balloon) was rather varied and collateral damage to the dermal/tracheal tissue was identified in 72.7% of the experimental animals. Accordingly, to standardize the HIFU irradiation sequence and to achieve a reliable and secure balloon burst, we conducted another series of animal experiments in which the mixture of perfluorocarbon was replaced with “limonene emulsion” (D-limonene micelle emulsified in physiological saline) as the balloon injection fluid. In all 6 animals, we succeeded in reopening the airway by achieving an instantaneous and timely balloon burst without definite skin/tracheal damage. We conclude that HIFU irradiation together with injecting the balloon with “limonene emulsion” is an improved method for safe tracheal release from a balloon occlusion.
出版者 Showa University Society
ISSN 0915-6380
資源識別子URI http://researchers-achievements.showa-u.ac.jp/dispGyoseki/?item_id=1033865&item_no=1
査読 あり
論文種別 原著